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Na***nal Institutes of Health (.gov) : Gene ResultIGF2 insulin like growth factor 2 [ (human)]
Jun 21, 2023 — This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth.
Na***nal Institutes of Health (.gov) : Gene ResultIgf2 insulin-like growth factor 2 [ (house mouse)]
Jun 21, 2023 — This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and ...
Pe***e also ask : What does high IGF2 mean?
An increase in IGF2 gene activity, which promotes growth, and a loss of H19 gene activity, which normally restrains growth, together lead to overgrowth in people with Beckwith-Wiedemann syndrome. In a few cases, Beckwith-Wiedemann syndrome has been caused by deletions of a small amount of DNA from the IC1 region.
Pe***e also ask : What is the normal range for insulin-like growth factor?
Normal ranges by age are: 182 to 780 ng/mL for ages 16 to 24. 114 to 492 ng/mL for ages 25 to 39. 90 to 360 ng/mL for ages 40 to 54.
Pe***e also ask : What causes high IGF2?
IGF2 can be produced in excess by tumour cells because of loss of imprinting (LOI) of the IGF2 gene. IGF2 produced by tumour cells can act in an autocrine manner by binding to isoform A of the insulin receptor (IR-A). This results in stimulation of mitosis and continued production of IGF2.
Pe***e also ask : What is IGF2 colon cancer?
IGF2 is the first gene discovered to be parentally imprinted. Loss of imprinting (LOI) or aberrant imprinting of IGF2 could lead to IGF2 overexpression, increased cell proliferation, and CRC development. IGF2 as a mitogen is associated with increased risk of developing colorectal neoplasia.
Me***nePlus (.gov) : IGF2 gene: MedlinePlus Genetics
Dec 3, 2021 — The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth ...
Un***ot : IGF2 - Insulin-like growth factor II - Sus scrofa (Pig)
Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the ...
Ge***ards : IGF2 Gene - Insulin Like Growth Factor 2
May 22, 2023 — This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth.