Na***nal Institutes of Health (.gov) : Hypoxia inducible factor pathway inhibitors as anticancer ...
by SK Burroughs · 2013 · Cited by 150 — Proliferation, C-MYC, ID2, IGF-2, NOS,, [76,78,103,104]. Stem cell maintenance, ABCG2, JARID1B, ... 1999;274(46):32631–32637. [PubMed] [Google Scholar].
Na***nal Institutes of Health (.gov) : Hypoxia-Inducible Factor Signaling in Pheochromocytoma
by I Jochmanová · 2013 · Cited by 175 — CBP = cAMP-response element-binding protein; Cul2 = cullin 2; ... IGF2 = insulin-like growth factor 2; IGFBP = insulin-like growth factor ...
Sc***ceDirect : Insulin-like Growth Factor 1 Induces Hypoxia ...
by R Fukuda · 2002 · Cited by 1020 — The insulin-like growth factor-1 (IGF-1)1 receptor tyrosine kinase (IGF-1R) is activated by binding either of its ligands, IGF-1 or IGF-2.
PL*** : Glucose-Induced O 2 Consumption Activates Hypoxia ...
by M Bensellam · 2012 · Cited by 96 — Glucose-induced O2 consumption creates an intracellular hypoxia that activates HIF1 and HIF2 in rat beta-cells, and this glucose effect contributes, together ...
Pe***e also ask : What is inhibiting hypoxia inducible factor?
Factor-inhibiting hypoxia-inducible factor (FIH) is an asparaginyl hydroxylase that catalyses the β-hydroxylation of an Asn-residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor and of highly conserved Asn-residues within the ubiquitous ankyrin repeat domain protein family.
Pe***e also ask : What are the targets of HIF 1?
The target genes regulated by HIF-1α are mainly EPO, VEGF, HO-1, ADM, and Glut-1.
Th***ournal of Biological Chemistry : Insulin-like Growth Factor 1 Induces Hypoxia- ...
by R Fukuda · 2002 · Cited by 1020 — IGF2 gene expression is up-regulated to the greatest extent of any gene in colon cancer cells relative to normal colonic epithelium (2), resulting in ...
Na***e Journal : Hypoxia-Inducible Factor 1: Control of Oxygen ...
by GL Semenza · 2001 · Cited by 377 — HIF-1 is a dimeric transcription factor of HIF-1α and HIF-1ß subunits (1, 2). Under nonhypoxic conditions the. HIF-1α subunit is subjected to ...
Ko***Med : a Valid Therapeutic Target for Tumor Therapy
by SS Hong · 2004 · Cited by 111 — Hypoxia-induced growth factors are known to promote cell proliferation and survival. Several growth factors, most notably insulin-like growth factor-2 (IGF2) ...
Jo***Wiley : The subtle side to hypoxia inducible factor (HIFα) regulation
by RL Bilton · 2003 · Cited by 230 — Inducible nitric oxide synthase [[56]] and haem oxygenase-1 [[57]] contain HRE within their promoters, whilst other genes, IGF-2 [[11]], IGF ...
Jo***Wiley : The subtle side to hypoxia inducible factor (HIFα) regulation
by RL Bilton · 2003 · Cited by 230 — Inducible nitric oxide synthase [56] and haem oxygenase-1 [57] contain HRE within their promoters, whilst other genes, IGF-2 [11], IGF binding ...
G-***sciences : Immunotag™ Insulin Receptor β Antibody
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, ...