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Pe***e also ask : How does ATF6 work?
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct.
Pe***e also ask : What is the ATF6 unfolded protein response?
ATF6(N) is a basic leucine zipper (bZIP)\u2013class transcriptional activator that, once untethered from the membrane, migrates to the nucleus to up-regulate ER protein\u2013folding chaperones and enzymes, such as GRP78/BiP (9, 10).
Pe***e also ask : Is ATF6 a protein?
The Unfolded Protein Response and Cellular Stress, Part A Upon ER stress, ATF6 translocates from the ER to the Golgi apparatus, where it is processed by two proteolytic steps by site-1 and -2 proteases; this generates a transcription factor (processed ATF6) that travels to the nucleus and alters gene expression.
Pe***e also ask : What is the name of the ATF6 gene?
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell. 1999;10:3787\u201399.
Na***nal Institutes of Health (.gov) : Gene ResultATF6 activating transcription factor 6 [ (human)]
Jul 18, 2023 — This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum ...
Ge***ards : ATF6 Gene - Activating Transcription Factor 6
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress.
Wi***edia : ATF6
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein ...
Bi***d Central : A lifetime of stress: ATF6 in development and homeostasis
by RF Hillary · 2018 · Cited by 176 — Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of ...
Sc***ceDirect : Activating Transcription Factor 6 - an overview
Active ATF6 is a basic leucine zipper transcription factor that translocates to the nucleus, binds the ER stress response element (ERSE), and upregulates ...
Un***ot : Cyclic AMP-dependent transcription factor ATF-6 alpha - ...
Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the ...
Sc***ceDirect : ATF6 - an overview
ATF6 is a type 2 membrane protein with a single transmembrane domain (Figure 1). Its NH2-terminal cytosolic domain is a transcription factor of the bZIP family.
On***e Mendelian Inheritance in Man : 605537 - ACTIVATING TRANSCRIPTION FACTOR 6; ATF6
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules (summary by Shen ...
eL*** : Pharmacologic ATF6 activating are ... - eLife
by R Paxman · 2018 · Cited by 81 — Here we show that 147-dependent ATF6 activation requires metabolic oxidation to form an electrophile that preferentially reacts with ER proteins ...