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Fr***iers : Implications of NKG2A in immunity and immune-mediated ...
by X Wang · 2022 · Cited by 7 — Upon crosslinking, NKG2A/CD94 delivers inhibitory signals for NK cells ... mediated by NK cells, thereby alleviating EAE in mice (102, 103).
Pe***e also ask : Which cells express NKG2A?
NKG2A expression is predominantly increased on CD56dim NK cells with CD56bright NK cells. NK cells are divided into CD56bright and CD56dim NK subsets. CD56bright NK cells are mainly responsible for cytokine secretion, whereas CD56dim NK cells are primarily responsible for cytotoxicity.
Pe***e also ask : What does NKG2A do for NK cells?
In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8+ T cells. It form heterodimer receptors with CD94, and targets the peptide-presenting human leukocyte antigen-E (HLA-E) molecules.
Pe***e also ask : What is the difference between NKG2C and NKG2A?
NKG2C delivers activating signals through immunoreceptor tyrosine-based activation motifs at the cytoplasmic tails of DAP12 transmembrane proteins (10), while NKG2A appears to inhibit NK activation via immunoreceptor tyrosine-based inhibitory motifs in the cytoplasm (11).
Pe***e also ask : What is the function of the NKG2D receptor?
The NKG2D receptor has an essential role in NK cell cytotoxicity through its binding to stress-inducible homologues of the HLA class I, MICA/B molecules [37] (Figure 1). NKG2E/H are splice variants of a single gene, KLRC3.
Na***nal Institutes of Health (.gov) : Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes ...
by P André · 2018 · Cited by 799 — NKG2A targeting with monalizumab is thus a novel checkpoint inhibitory mechanism promoting anti-tumor immunity by enhancing the activity of both T and NK cells, ...
Na***nal Institutes of Health (.gov) : Disruption of the NKG2A:HLA-E Immune Checkpoint Axis ...
by JG Fisher · 2022 · Cited by 4 — Ligation of the inhibitory receptor NKG2A by its ligand HLA-E negatively regulates the activation of natural killer (NK) cells, as well as subsets of CD8+ T ...
Ce*** : The Inhibitory Receptor NKG2A Sustains Virus
by AS Rapaport · 2015 · Cited by 73 — NKG2A is an inhibitory receptor expressed on a subset of NK cells and activated CD8+ T cells. It belongs to a family of lectin- like cell ...
aa***ournals : The NKG2A–HLA-E Axis as a Novel Checkpoint in the Tumor ...
Together, these observations designated a role for NKG2A as an acquired resistance mechanism (102). This concept is further substantiated by preclinical in ...
Th***merican Association of Immunologists : KIR − NKG2A + NK Cells Have More Dynamic Migration ...
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57−KIR−NKG2A+ NK Cells ... donors (nIR-,total cells = 102, nNKG2A+,total cells = 101 cells).
Wi*** : NKG2A inhibits NKG2C effector functions of T cells
by DF Angelini · 2011 · Cited by 53 — (2003) Expression and function of. KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Blood 102, 1797–1805.
Ar***ve ouverte HAL : Role of NKG2a/c+CD8+ T cells in pathogenic versus non- ...
by N Huot · 2021 · Cited by 4 — Genome-wide transcriptome analysis of NKG2a/c ... Inhibitory natural killer (NK) cell receptors, such as NKG2A, ... Blood 102, 577–584.
Rn***stems : Development of Antibodies Specific for NKG2 Family ...
NKG2A, NKG2C and NKG2E/H are members of the NKG2 family of type II transmem- ... 102. 103. 104. Antibody Staining of NKG2A Transfectants. FIGuRE 1.