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keap1-cul3 interaction,nrf2 e79k,is a redox regulated substrate adaptor protein for a cul3-dependent ubiquitin ligase
Na***nal Institutes of Health (.gov) : Gene-expression signature regulated by the KEAP1-NRF2 ...
by A Namani · 2018 · Cited by 79 — This 17-gene signature provides potential biomarkers and therapeutic targets for HNSCC cases in which the NRF2 pathway is activated. Keywords: ...
Na***nal Institutes of Health (.gov) : Keap1 is a redox-regulated substrate adaptor protein for ...
by DD Zhang · 2004 · Cited by 1339 — In this report, we demonstrate that Keap1 functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin comlex Keap1 assembles into a ...
Pe***e also ask : What is KEAP1 mutation in cancer?
KEAP1 is altered in 3.43% of all cancers with lung adenocarcinoma, squamous cell lung carcinoma, non-small cell lung carcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].
Pe***e also ask : What is the KEAP1-NRF2 signaling pathway in lung cancer?
On the other hand, the NRF2/KEAP1 pathway is a mutated signaling pathway in human lung cancer and some pro-oncogenic functions of NRF2 provide an advantageous condition for the progression of cancer cells. NRF2 is an important regulator of metabolic reprogramming and cancer proliferation.
Pe***e also ask : What does KEAP1 protein do?
Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3-based E3 ubiquitin ligase. Keap1 regulates the activity of Nrf2 and acts as a sensor for oxidative and electrophilic stresses.
Pe***e also ask : What is KEAP1 in Nsclc?
In NSCLC, KEAP1 LOF mutations and NFE2L2 GOF mutations mediate an array of tumor-promoting functions, spanning from tumor progression (by means of oncogenic cooperation) and metabolic reprogramming to resistance to chemotherapy, radiotherapy, and targeted agents.
Bi***ID : Role of human Keap1 S53 and S293 residues in modulating the ...
Keap1 is deemed as a suppressor of Nrf2 in cytoplasm by sequestrating Nrf2 to proteolysis as an adapter of the Cul3-Rbx1 E3 ubiquitin comlex
AM***O : KEAP1 (NM_012289) Human 3' UTR Clone, SC207333
3`UTR clone of kelch-like ECH-associated protein 1 (KEAP1) transcript variant 2 for miRNA target validation. Product Specifications ...