bi***iv : Rudimentary Structure-Activity-Relationship study of the ...
May 20, 2022 — In line with our quest for dihydrofolate reductase (DHFR) ... In addition,.comound 10 (RC50 ˃ 400 µM) was over ∼ 4-fold less active than ...
bi***iv : Rudimentary Structure-Activity-Relationship study of the ...
by D Dize · 2022 · Cited by 2 — antitrypanosomal analogs as inhibitors of DHFR was achieved, together with ... with a median reducing concentration (RC50) of 96.37 µM.
MD*** : Preliminary Structure–Activity Relationship Study of the ...
by D Dize · 2022 · Cited by 2 — enzyme dihydrofolate reductase (DHFR) that are thought to be essential ... activity with a median reducing concentration (RC50) of 96.37 µM.
Na***nal Institutes of Health (.gov) : Influence of Reduced Folate Carrier and Dihydrofolate ...
by SA Yoon · 2010 · Cited by 68 — Dihydrofolate reductase (DHFR) is a key enzyme of the folate cycle ... Methotrexate (MTX) is a potent inhibitor of the DHFR, which plays a ...
Am***can Physiological Society Journal : Electronic cigarette exposure causes vascular endothelial ...
by MA El-Mahdy · 2022 · Cited by 20 — relaxation (RC50) were calculated from fitted ACh/SNP-relaxa- ... (1:500 dilution), anti-dihydrofolate reductase enzyme (DHFR;.
Am***can Physiological Society Journal : NADPH Oxidase Activation and eNOS Uncoupling
by MA El-Mahdy · 2022 · Cited by 20 — Ach and SNP concentrations that induced 50 % relaxation (RC50) were ... dilution), anti-DHFR (1:1000 dilution), and anti-nitrotyrosine ...
Go***e Patents : WO2001053276A1 - Dihydrofolate reductase inhibitors
The dihydrofolate reductase (DHFR) domain of the Plasmodium falciparum ... [K 1(rC 50) =» 3nM, selectivity = 376] is the of choice (Table 6).
EM***Press : Structure and expression of cDNA and genes for human ...
by A Zilberstein · 1986 · Cited by 683 — together with a plasmid containing mouse DHFR cDNA fused to the SV40 promoter, ... and poly(rI)(rC) 50 ig/ml for 3.5 h; lane 3: priming and cycloheximide.
VC***cholars : Characterization of a Staphylococcal Trimethoprim Resistance ...
by JP Coughter · 1986 — the concentration of the drug required to reduce enzyme activity by 50 percent) for the DHFR of these strains. In some cases however, the rc50 was.