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Na***nal Institutes of Health (.gov) : Gene ResultRBM10 RNA binding motif protein 10 [ (human)]
Jul 9, 2023 — This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with ...
Na***nal Institutes of Health (.gov) : RBM10: Harmful or helpful‐many factors to consider - PMC
by JJ Loiselle · 2018 · Cited by 26 — RBM10 is an RNA binding motif (RBM) protein expressed in most, if not all, human and animal cells. Interest in RBM10 is rapidly increasing and its clinical ...
Pe***e also ask : What is the function of RBM10?
RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). RBM10-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma.
Pe***e also ask : What are the domains of RBM10?
RBM10 has two RNA-binding domains in the N-terminal region: the RRM1-C4 ZnF di-domain and RRM2 domain. RBM10 isoforms 1 \u2013 4 are determined by the inclusion or exclusion of the region encoded by exon 4 (box at residues 68\u2013144) and of a Val residue at 354 (open triangle) (see also Fig. 3).
Pe***e also ask : What is RBM in biology?
RBM5 is a known modulator of apoptosis, an RNA binding protein, and a putative tumor suppressor. Originally identified as LUCA-15, and subsequently as H37, it was designated "RBM" (for RNA Binding Motif) due to the presence of two RRM (RNA Recognition Motif) domains within the protein coding sequence.
Sc***ceDirect : RBM10: Structure, functions, and associated diseases
by A Inoue · 2021 · Cited by 21 — RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of primary transcripts. Recently, research on RBM10 has ...
Fr***iers : RBM10 Regulates Tumor Apoptosis, Proliferation, and ...
by Y Cao · 2021 · Cited by 15 — RBM10 is abnormally expressed in the lung, breast, and colorectal cancer, female genital tumors, osteosa, and other malignant tumors. It ...
Fr***iers : RBM10 Deficiency Is Associated With Increased Immune ...
by B Liu · 2021 · Cited by 5 — In this study, we found that the number of neoantigens per mutation was slightly higher in tumors with RBM10 mutations, and clones with RBM10 ...
Ge***ards : RBM10 Gene - RNA Binding Motif Protein 10
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins ...
Wi***edia : RBM10
RNA-binding motif 10 is a protein that is encoded by the RBM10 gene. This gene maps on the X chromosome at Xp11.23 in humans. RBM10 is a regulator of ...
Ce*** : UTR Processing to Regulate Cardiac Hypertrophy
by N Mohan · 2018 · Cited by 36 — RBM10 binds the pre-mRNA UTR, assembles the Star-PAP, and guides this specifically to mRNAs encoding anti-hypertrophy regulators ...
On***e Mendelian Inheritance in Man : 300080 - RNA-BINDING MOTIF PROTEIN 10; RBM10
HGNC Approved Gene Symbol: RBM10. Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,145,221-47,186,813 (from NCBI).
Jo***al of Clinical Investigation : Deficiency of the splicing factor RBM10 limits EGFR ...
by S Nanjo · 2022 · Cited by 14 — RBM10 deficiency decreased EGFR inhibitor efficacy in patient-derived EGFR-mutant tumor models. RBM10 modulated mRNA alternative splicing of the mitochondrial ...